Abstract
Many plants have the property of wound healing, but most of the people are using costly allopathic medicine for the wound. This might be due to lack of awareness about the traditional uses and lack of scientific study of ethnomedicinal plants. So, this study aimed to carry out the antibacterial and antioxidant activity of two medicinal plants which are used traditionally for wound healing activity, i.e.,Mimosa rubicaulis and Reinwardtia indica. Different parts of Mimosa rubicaulis (root, stem, and leaves) and Reinwardtia indica (flower and leaves) were used for the study. Extractions were done by maceration using ethanol as solvent. Antibacterial activity was carried out by the well diffusion method, and antioxidant activities were screened by DPPH radical scavenging and NO scavenging assays. Extract of M. rubicaulis has shown a weak zone of inhibition towards S. aureus and P. vulgaris whereas R. indica has shown no zone of inhibition towards selected bacterial strains. Leaf, root, and stem extracts of M. rubicaulis have shown potent antioxidant activity, i.e., IC50 value of 9.8 µg/ml, 10.19 µg/ml, and, 13.64 µg/ml, respectively. Similarly, leaf extract of R. indica exhibited antioxidant activity with an IC50 value of 19.73 μg/ml. The percentage inhibition of NO radicals of root and stem of M. rubicaulis and leaves of R. indica was 31%, 21%, and 22%, respectively. Out of these two plant species, M. rubicaulis had shown antibacterial activity towards selected microorganism, but antioxidant activity was shown by both plant species. These properties on above mentioned two plant species might help for the development of a marketed formulation for antibacterial and wound-healing agent since wound healing is promoted by antibacterial and antioxidant activities.
Highlights
In developing countries, infectious diseases due to bacteria are the main causes of morbidity and mortality among the general population [1]
Extraction Yield Value. e extract yield % was calculated using equation (3). e extract yield % of the plant sample is shown in Table 1. e extract yield percentage was relatively higher in root and leaves of M. rubicaulis, and flower of R. indica while relatively lower in the stem of M. rubicaulis and leaves of R. indica
Cefpodoxime had shown zone of inhibition towards E. coli (36 mm), P. vulgaris (34 mm), and S. aureus (24 mm), respectively. e root extract of M. rubicaulis was found to have a weak zone of inhibition towards S. aureus, i.e., 12 mm, and leaves and stem extracts were found to have a weak zone of inhibition towards P. vulgaris, i.e., 11 mm and 11 mm, respectively
Summary
Infectious diseases due to bacteria are the main causes of morbidity and mortality among the general population [1]. Various antibiotics have been discovered for the treatment of infectious diseases. It was assumed that infectious diseases will no longer exist after the discovery of antibiotics [2]. The increased use of antibiotics has led to the drug-resistant strain of bacteria which in turn has resulted in the emergence of new infectious diseases. It is a necessity and challenge to develop new antibiotics with novel mechanisms of action to overcome the problem of antibiotic resistance [3]. At might be due to the generation of free radicals [6] which are capable of attacking the healthy cells of the body, causing them to lose their structure and function [7] Today’s another issue is that many people in this fastgrowing world are suffering from diseases such as heart disease, cancer, Alzheimer’s disease, neurological disorders, hypertension, diabetes mellitus, renal failure, liver diseases, and early aging [4] due to exposure on various exogenous sources such as radiations, various toxic chemicals, and pollution [5]. at might be due to the generation of free radicals [6] which are capable of attacking the healthy cells of the body, causing them to lose their structure and function [7]
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