Abstract

Used database research ODA (Evaluation of the effectiveness and therapeutic response to Preductal OD 80 mg in everyday practical use for the treatment of stable angina), which was conducted in 56 cities of the Russian Federation. The analysis was carried out in the Central, North-West, Volga districts and regions united by the territorial principle - Southern + North Caucasian + Crimea + Sevastopol and Ural + Siberian + Far Eastern. By region, there were no differences in the ratio of men and women included in the observation, the number of smoking patients (about 15%), overweight (about 80% of patients), arterial hypertension (exceeding 85%),dyslipidemia (over 90%), and atrial fibrillation (met at each 8-10 included patient). The proportion of patients older than 65 years was greater in the Central, North-West and Ural regions. Unfavorable heredity in coronary artery disease is more common in the Southern, Central and Ural regions. More than 2/3 of the patients had low physical activity, and in the South - their number reached ¾ of all included in the observation. The largest number of patients with diabetes was in the Central and North-West regions (every fourth patient), in the Ural region every fifth. The lowest frequency of statin prescribing was in the Volga region. The smallest number of those receiving RAS inhibitors was in the North-West, Ural and South regions. Beta blockers took more than 80% of patients. Only 35% of patients had a target systolic blood pressure. The smallest proportion of people with target blood pressure values was in the NorthWest and South regions. Adding TMZ OD to therapy or replacing previous therapy with trimetazidine on TMZ OD in all regions resulted in a significant (p <0.001) decrease in the incidence of angina attacks by as early as 1 month of therapy and the antianginal effect increased by the third month of treatment. By the third month of treatment, the average frequency of angina attacks was the lowest in the North-Western and Ural regions (significantly lower than even in the Central region) and remained higher only in the Volga region compared to the Central, North-Western and Ural regions. During follow-up, treatment compliance increased significantly in all regions. The fight against major risk factors remains insufficient and efforts should be made to change the situation in all regions of the Russian Federation. The inclusion of trimetazidine in therapy in the new TMZ OD dosage form allows to obtain a pronounced antianginal effect and increase adherence to therapy. Low adherence can be overcome by careful observation and closer contact between doctors and patients.

Highlights

  • И шемическая болезнь сердца является широко распространенным заболеванием, вносит существенный вклад в общую смертность взрослого населения и существенно ухудшает качество жизни людей

  • By region, there were no differences in the ratio of men and women included in the observation, the number of smoking patients (about 15%), overweight (about 80% of patients), arterial hypertension (exceeding 85%),dyslipidemia (over 90%), and atrial fibrillation (met at each 8-10 included patient)

  • Beta blockers took more than 80% of patients

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Summary

Summary

The goal evaluation of the effectiveness of treatment with the new TMZ OD dosage form in different regions of the Russian Federation and regional differences in the clinical characteristics of patients with coronary artery disease included in the observation, the nature of their therapy, the presence and degree of correction of modifiable risk factors in real clinical practice. Нами в условиях многоцентрового открытого наблюдательного исследования ОДА (Оценка эффективности и терапевтического ответа на Предуктал ОД 80 мг при повседневном практическом использовании для лечения стабильной стенокардии) впервые была проведена оценка эффективности и безопасности препарата у 3 066 пациентов, включенных в наблюдение в 56 городах РФ. В Центральном округе было включено 988 человек, Целью настоящего исследования явилась оценка в Северо-Западном – 370 человек, в Южном – 357 человек, эффективности лечения новой лекарственной формой в Приволжском – 643 человека и Уральском – 708 человек. Материалы и методы Для проведения анализа по регионам РФ нами была использована база данных, полученная в результате многоцентрового открытого наблюдательного исследования ОДА. Клиническая характеристика пациентов с ИБС в разных регионах, включенных в исследование ОДА

Наличие ИМ в анамнезе
Южный Приволжский Уральский
Полностью неприверженные
Findings
Обсуждение В многоцентровом наблюдательном исследовании
Full Text
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