Abstract
Sambucus ebulus L. (Caprifoliaceae) herbs are widely used in Turkish folk medicine for the treatment of rheumatic pain. Anti-inflammatory and anti-arthritic effects of the extracts as well as fractions obtained from the aerial parts are investigated by usingin vitro (PLA2-inhibitory activity) andin vivo test models (carrageenan-and serotonin-induced hind paw edema in mice, and adjuvant-induced chronic arthritis in rats). Through the fractionation of the MeOH extract by successive extractions with hexane, chloroform, and n-butanol, an anti-inflammatory principle is isolated from the butanolic extract and its structure is elucidated as chlorogenic acid.
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