Abstract
Objectives: Diarrhoeal disease is often a leading source of mortality and morbidity, especially among children in developing countries causing a major healthcare problem. As per suggestion of WHO, treatment of diarrhoea with traditional medicine is the main focus of our present studies. The present study is designed to evaluate the anti-diarrhoeal activity of crude methanol extract of Urena sinuata L. (U. sinuata) and its fractions. Methods: Crude methanol extracts are obtained by in vacue methods and its fractionating is done by Kupchan partitioning method. The anti-diarrhoeal activity is screened by castor oil-induced diarrhoea, castor oil-induced enteropooling and gastrointestinal motility test. Results: The diarrheal severity was reduced significantly (P
Highlights
Diarrhoeal disease is often a leading source of mortality and morbidity, especially among children in developing countries causing a major healthcare problem (Chitme et al, 2004)
The present study is designed to evaluate the anti-diarrhoeal activity of crude methanol extract of Urena sinuata L. (U. sinuata) and its fractions
Castor oil induced enteropooling All of the extracts showed noticeable effect in castor oil induced entropooling test in the rats
Summary
Diarrhoeal disease is often a leading source of mortality and morbidity, especially among children in developing countries causing a major healthcare problem (Chitme et al, 2004). Due to diarrhoea, that 50% of deaths attributed to diarrhoea combined with respiratory disease were due to diarrhoea, and that one-third of deaths due to combined measles with diarrhoea or respiratory disease were due to diarrhoea. With these assumptions, using the most recently available national verbal autopsy data (1999-2003), diarrhoea accounted for 5.4 deaths per 1,000 children in Bangladesh (Baqui et al, 2001; Luby et al, 2008). It requires a rise in the fluidity, volume and frequency of going number two or three, abdominal pain associated with increased secretion and decreased absorption of fluid thereby loosing water and electrolytes (Fontaine; Field et al, 1989)
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