Abstract
The goal of the present study is to evaluate The Evaluation the effect of Analgesic Activity of Coenzyme Q10 ointment in mice. Materials and Methods: Fifteen healthy male albino mice were selected for this study. The animals were divided into three groups of five animals for each group. Group 1 served as a control and was applied vaseline ointment topically on fore and hind limb. Group 2 and 3 were applied topically Coenzyme Q10 ointment 4%, 8% respectively on fore and hind limb. The onset and duration of analgesic effect of Coenzyme Q10 ointment were evaluated in mice by utilizing a Hot-Plate test at 55±1˚C. Latency reaction time was recorded after 3min. and (10- 60 min) after ointment applied. The prolongation of latency times compared with the values of the control was used to express about analgesic effects of Coenzyme Q10 ointment and the percentage of Maximal Possible Effect (MPE) was calculated. Results: The Coenzyme Q10 ointment at concentrations (4%, 8%) produced analgesic effect in mice after 3 min, respectively in comparison with control. The percentage of maximum possible effect (MPE) was significantly increased in group treated with (4%,8%) Coenzyme Q10. Conclusions: The Coenzyme Q10 ointment have a good analgesic activity in mice after 3 minutes of topical application and prolong the duration of analgesia more than 40 minutes depending on concentration of Coenzyme Q10 ointment.
Highlights
Coenzyme Q10 ointment were prepared in two different concentration by mixing (4, 8) g from Coenzyme Q10 powder in 100 gm Vaseline respectively to give final concentration (4%, 8%) W\W with continuous mixing using a glass rode until homogenous ointment were formed.The ointment were kept in plastic containers and stored in refrigerator at 40C until used
Topical application of Coenzyme Q10 drug at (4%,8%) create good analgesic effects in comparison with control treated with Vaseline only .The results for increasing the pain reaction time of the Coenzyme Q10 drug at (4%) and (8%) showed that the drug has a highly significant difference after (3 and 10, 20, 30, 40,50, 60) min
Reaction time was augmented from 0 % in control group after 3 min. to (5.08, 15.87)% respectively according to the concentration of Coenzyme Q10 at (4% and 8%)
Summary
The aim of this study is to examine analgesic effect of Coenzyme Q10. The aim of the present study is to prepare different concentration of Coenzyme Q10 ointment to examine the analgesic effects of topical application in mice by using a hot plate test.
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