Abstract
ABSTRACT The aim of this study was to evaluate the topical application of alcoholic extracts of Dipteryx alata Vogel almonds and bark in skin wound healing in mice. Fifty-four C57BL/6 mice were equally distributed into three groups: Control, Almond, and Bark. A 9 mm skin fragment was resected from the dorsal region of the animals’ thorax. The wounds were submitted to topical application of base cream (vehicle), 10% hydroalcoholic almond extract, or bark extract twice a day. Macroscopic, histological, and immunohistochemical evaluations were conducted on the 7th, 14th, and 21st postoperative days. No significant difference was observed regarding skin wound area among groups, with the parameter presenting only a temporal effect on healing (p>0.05). The almond and control groups exhibited more intense collagenization than the bark group (p<0.05). Dipteryx alata Vogel showed to be inert in the wound healing process in mice.
Highlights
Skin wounds represent one of the most important pathological processes in humans and animals (Han and Ceilley, 2017)
This study was approved by the Ethics Committee on the Use of Animals (CEUA) of the Federal University of Mato Grosso (UFMT), Cuiabá Campus, under Protocol No 23108.143811/201677
The samples of Dipteryx alata Vogel plants used in the present experiment were collected on the campus of the Federal University of Mato Grosso (UFMT), in Cuiabá, Brazil (15°36'38.9" S; 56°03'50.5" W)
Summary
Skin wounds represent one of the most important pathological processes in humans and animals (Han and Ceilley, 2017). Skin wounds are related to considerable interferences in the quality of life, pain, and long-term hospitalization, in addition to high costs (Nussbaum et al, 2018) The healing of these wounds is a complex and dynamic process capable of restoring cellular structures that culminate in tissue integrity (Campos et al, 2007). Tissue repair is a systemic process, it is necessary to favor ideal local conditions with the removal of devitalized tissue and exudates, the promotion of wound bed revascularization, and the creation of a controlled humid environment for successful wound repair (Negua et al, 2018). Despite the numerous techniques and products tested and used in skin wound healing, a gold standard remains unavailable (Giannoudis and Tosounidis, 2020)
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