Evaluation of the adaptogenic activity of Tecoma stans flowers extract

Abstract

Aim: The present investigation aimed to screen the adaptogenic activity of the Tecomastans flower extract. Methods: Anoxia and immobilization stress models were used in the study. Results: Anoxia stress tolerance time in mice In the anoxia stress tolerance test, the time taken for the mice to exhibit clonic convulsions was taken as the endpoint. The graded doses (125, 250, 500 mg/kg) of the test extract demonstrated dose and duration dependent significant delay in clonic convulsions on the 7th, 14th and 21st days compared to the control group. The anti-stress effect of the higher dose (500 mg/kg) of the test extract was found closer to that of the standard drug. Immobilization Stress Effect on Biochemical Parameters: Immobilization stress significantly elevated the serum cholesterol, glucose, triglycerides, and BUN levels in stress control rats compared to the normal control group. Animals pretreated for ten days with test extract at different dose levels (125, 250 and 500 mg/kg) showed dose-dependent falls in all the biochemical parameters, as compared to the stress control rats. Effect on the Weight of Organs: An increase in liver, adrenal glands weight and decrease in spleen weight were seen in Immobilization stressed rats. Ten days pretreatment with graded doses of METSF significantly and dose-dependently ameliorated the Immobilization stress-induced altered organs weight. Conclusion: In conclusion, the methanolic extract of Tecomastans flowers exhibited dose-dependent significant antistress activity against stress-induced animal models.