Abstract
The aim of this study was to evaluate clinically and by non invasive instrumental evaluations the efficacy and tolerability of a cosmetic treatment containing an innovative active ingredient, ethyl ximenynate, in the prevention of dark circles under the eyes and blemishes of skin aging on the eye profile. Evaluations were performed at baseline and after 2 and 4 weeks of treatment on 22 volunteers; the study was planned as a double blind half-face trial. Data showed a trend towards a lifting of the eyelid skin; all investigator scores (eye puffiness, skin smoothness, roughness and dryness) decreased. In addition, profilometric results confirmed the anti-wrinkles efficacy of the active product and its lifting action, while those related to spectrophotometry underlined the decongestant effect on dark circles that appeared, at the end of the study, to be less marked. The improvement of skin microcirculation and capillary resistance and vascular tone in the eye area underlines a general mitigation of all relevant skin imperfections and blemishes of skin aging on the eye profile. The active ingredient was shown to be effective for the cosmetic treatment of the periocular area.
Highlights
Midfacial aging is a natural process that affects every anatomic component of the midface
Midfacial aging is directly related to changes that occur in the cheek and in the periocular region, a specific area of the skin characterized by micro-anatomic features which makes it different from the surrounding facial skin
Obtained results highlighted as the active product determined, at the end of the study, a clinically and statistically (Dunnett test p < 0.05 T4 vs. T0) significant improvement vs. baseline of the following items:
Summary
Midfacial aging is a natural process that affects every anatomic component of the midface. The epidermis is thinner and very sensitive, characterized by a reduced barrier function and by an abnormal hydrolipidic layer; the dermis is thinner with a reduced collagen and elastin content which makes the skin less tense and more prone to becoming slack and relaxed. This may cause a decreased blood and lymph flow resulting in fluid accumulation and pseudo-edema with further progression of the extrusion of the lower eyelid. Treatment of the periocular area should be oriented to the reduction of predisposing factors (smoke, free radicals, UV exposure) and improvement of skin microcirculation, both for vascular and lymphatic compartments [1,2]
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