Abstract
ABSTRACT The responses of sand rats and rats to disturbances of their glucose metabolism were tested. Despite their latent diabetes, the sand rats had normal glucose tolerance. They did not show signs of starvation diabetes. Their responses to exogenous and endogenous (tolbutamide-stimulated) insulin were greater than those of laboratory rats. Acute insulin deficiency was induced with mannoheptulose. Both species responded with similar levels of hyperglycaemia, although the response of the sand rat was somewhat slower. The only test used here which indicated a metabolic difference related to latent diabetes, was the induction of transient intolerance to glucose by cortisol. These results suggest that latent diabetes is not associated with any marked metabolic abnormality in the unchallenged sand rat, despite the ease of induction of diabetes by caloric loading.
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