Abstract
Introduction. Bone disease is a common complication of cystic fibrosis (CF). To date, there have been no reports on the effectiveness of teriparatide, recombinant human parathyroid hormone, to treat CF-related bone disease. Case Presentation. We report on four patients with CF-related bone disease who were treated with teriparatide. Three patients completed two years of therapy with teriparatide, and all had significant improvements in their bone mineral density (BMD). One patient was unable to tolerate teriparatide and discontinued treatment 1 week into therapy. Conclusion. Teriparatide may be a potential treatment option for CF-related bone disease. This report highlights the need for further investigation into the use of teripartide in the CF population.
Highlights
Bone disease is a common complication of cystic fibrosis (CF)
The major contributing factors to bone disease in CF include vitamins D and K malabsorption, poor nutritional status, physical inactivity, chronic inflammation, glucocorticoid therapy, delayed puberty, and hypogonadism [4,5,6]. These factors result in decreased bone mineral density (BMD), osteopenia, osteoporosis, fragility fractures, and kyphosis, which can cause significant morbidity and potential exclusion from lung transplantation candidacy [7]
Studies on the use of teriparatide, recombinant human parathyroid hormone, in CF-related bone disease have not been reported to date
Summary
Cystic Fibrosis (CF), caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, is a common lethal genetic disease among Caucasians. New complications from CF have emerged, including CF-related bone disease [1,2,3]. The major contributing factors to bone disease in CF include vitamins D and K malabsorption, poor nutritional status, physical inactivity, chronic inflammation, glucocorticoid therapy, delayed puberty, and hypogonadism [4,5,6]. These factors result in decreased bone mineral density (BMD), osteopenia, osteoporosis, fragility fractures, and kyphosis, which can cause significant morbidity and potential exclusion from lung transplantation candidacy [7]. Studies on the use of teriparatide, recombinant human parathyroid hormone, in CF-related bone disease have not been reported to date
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
