Evaluation of Synergistic Formulation Extract of Traditional Contraceptive Plants for Acute Oral Toxicity

Abstract

In folk medicine, certain plants are used to prevent pregnancy. The purpose of the study was to evaluate the synergistic formulation of conventional contraceptive herb’s acute toxicity. Acute toxicity refers to a negative change that happens right away after exposure to a drug. Using OECD-423 recommendations, the acute toxicity of crude oil and its aqueous extract was assessed after oral administration to female mice. 2000mg/kg of a high extract was provided as a single dosage, and the effects on mortality, behavioural pattern, and spontaneous movement (Locomotor activity) of the body were assessed. The upper limit of 2000 mg/kg did not result in any fatalities. The results indicated that both aqueous and petroleum ether had LD50 values more than 2000 mg/kg. Consequently, plant synergistic extract is safe. This research can be used to determine the dose structure for future experiments evaluating the efficacy of natural contraceptive herbs.