Abstract
In vitro study on the efficacy of zinc oxide and titanium dioxide nanoparticles against metallo beta-lactamase and biofilm producing Pseudomonas aeruginosaMary Grace Vincent, Neetu Peedikayil John, Narayanan PM, Vani C and Sevanan Murugan
Highlights
Cefotaxime—a beta-lactam antibiotic is the most preferable antibiotic given during severe infections (Badar and Navale, 2012)
The present study evaluates the synergistic association between Cefotaxime and aqueous garlic (Allium sativum) extract (AGE) on extended spectrum beta-lactamase (ESBL) and Ambler Class C (AmpC) co-producing Escherichia coli strains from skin and soft tissue infections (SSTIs)
Due to the increased abuse of synthetic antibiotics and the increasing spread of strains with multi-drug resistance, there is a need for an alternative antibacterial agent
Summary
Cefotaxime—a beta-lactam antibiotic is the most preferable antibiotic given during severe infections (Badar and Navale, 2012). Resistance toward beta-lactams in clinical strains is primarily caused due to the hydrolysis of the antibiotic by a betalactamase enzyme. Extended-spectrum beta-lactamases (ESBLs) are enzymes susceptible to clavulanate and they hydrolyze penicillins, extended-spectrum cephalosporins, and monobactams (Thomson, 2010). Ambler Class C (AmpC) class beta-lactamases are cephalosporinases which are poorly inhibited by clavulanic acid, and can hydrolyze cephamycins as well as other extendedspectrum cephalosporins (Sasirekha and Shivakumar, 2011). When ESBL and AmpC beta-lactamase co-exist, they mask each other; their detection is difficult. They cause an increase in the minimum inhibitory concentration (MIC) values for beta-lactam antibiotics (Sundin, 2009)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
