Abstract
The aim of this study was to evaluate histologically, three types of calcium sulfate - Merck (Brazil), Surgiplaster (Italy) and Capset (USA) - in surgically created defects on rabbit femurs. Twenty male New Zealand rabbits were used. Two surgical bone defects (5 mm diameter x 8 mm depth) were created on each distal epiphysis using a #3 Dentoflex trephine bur. Defects were filled with: group 1 - di-hydrated calcium sulfate (Merck); group 2 - Capset (Lifecore-USA); group 3 - Surgiplaster (Classimport-Italy); group 4 – control (blood clot). The animals were sacrificed 30, 60, 90 and 180 days postoperatively. Semi-serial 6-mm-thick sections were obtained, stained with hematoxylin and eosin and examined under light microscopy. Bone defects treated with calcium sulfate exhibited new bone formation regardless of the product trademark.
Highlights
Several surgical procedures using biological or synthetic bone substitutes have been developed for the treatment of bone defects to promote closure with new bone tissue with morphological and functional characteristics similar to those of the original tissue[1,2,11,12,17]
Calcium sulfate used as bone implant material has been reviewed by several authors . 1,2,3,8,10,12,17,20 Calcium sulfate or plaster of Paris has a long clinical history as a bone graft material substitute in various skeletal sites including mandibular[1], craniofacial[12] and long bone defects[10,11,12,13,14,15] and benign bone lesions[12]
Calcium sulfate has been used as a barrier in guided tissue regeneration by physically halting soft connective tissue proliferation by means of the osteopromotion principle[4,8,18,19,25] The aim of this study was to evaluate histologically the tissue reaction to three types of calcium sulfate: di-hydrate calcium sulfate (Merck, Brazil), Capset (Lifecore Medicals, USA) and Surgiplaster (Classimport, Italy) when used in surgical cavities on femurs epiphisis rabbits
Summary
Several surgical procedures using biological or synthetic bone substitutes have been developed for the treatment of bone defects to promote closure with new bone tissue with morphological and functional characteristics similar to those of the original tissue[1,2,11,12,17]. The autogenous bone ís the most widely used graft material due its favorable biological properties in terms of the formation of new bone tissue. 1,2,3,8,10,12,17,20 Calcium sulfate or plaster of Paris has a long clinical history as a bone graft material substitute in various skeletal sites including mandibular[1], craniofacial[12] and long bone defects[10,11,12,13,14,15] and benign bone lesions[12]. Calcium sulfate has been used as a barrier in guided tissue regeneration by physically halting soft connective tissue proliferation by means of the osteopromotion principle[4,8,18,19,25] The aim of this study was to evaluate histologically the tissue reaction to three types of calcium sulfate: di-hydrate calcium sulfate (Merck, Brazil), Capset (Lifecore Medicals, USA) and Surgiplaster (Classimport, Italy) when used in surgical cavities on femurs epiphisis rabbits
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