Abstract
A semi-practical test was conducted in order to evaluate the suppression effect of a total release aerosol (TRA) containing a newly developed acaricide, amidoflumet, on the house dust mite, Dermatophagoides farinae Hughes. Three pieces of carpet sized 80 × 80 cm with harbored mites were maintained by distinct procedures: (1) TRA treatment with weekly vacuuming (Chemical treatment), (2) weekly vacuuming only without TRA (Control A) and (3) 5 vacuumings a week without TRA (Control B). The number of live mites and the mite allergen levels (Der f I and Der f II) obtained from 25 cm^2 area of the carpets were compared with up to 57 days posttreatment. The number of live mites in the chemical treatment carpet was reduced to 1% of the pretreatment level at day 8 and was maintained at the low level (< 5 living mites/25 cm^2) until day 43. The quantities of Der f I and Der f II in the chemical treatment carpet decreased to 45% and 55% of the pretreatment level, respectively. For the control A carpet, the number of live mites and the allergen levels kept increasing for 57 days, and the number of live mites, Der f I and Der f II at day 57 reached 36, 14 and 25 times more than the day 0 levels, respectively. In the contol B carpet, the numbers of live mite between day8 and day 22 were greater than that of day 0. The mite allergen levels of the control B fluctuated until day 22 and then decreased to 6% (Der f I) or 4% (Der f II)of the day 0 levels. This was due to less absolute weight of the collected dust in the control B. Consequently, a treatment of the amidoflumet TRA combined with weekly vacuum cleaning was considered to be a more effective strategy than frequent cleaning (5 times/week) alone for the house dust mite and mite allergen. It was also suggested that more frequent cleanings with a TRA treatment would enhance the allergen avoidance effect.
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