Abstract
Abstract Insect growth regulator (IGR) activity of 52 substituted oxime ethers was evaluated against an important polyphagous lepidopteran pest, Spodoptera litura (F.) (Lepidoptera: Noctuidae). Several compounds produced symptoms comparable to exogenously applied juvenile hormone. Maximum IGR activity was exhibited by 4′-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3′-buten-2′(E)-ketoxime-N-O-alkyl ether with an ED50 (morphological) of 40 μg g−1 body weight, compared with 20 μg g−1 of juvenile hormone (JH) III. Two more compounds, namely, 4′-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3′-buten-2′(Z)-ketoxime-N-O-methyl propyl ether (ED50 of 192 μg g−1) and 4′-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3′-buten-2′(E)-ketoxime-N-O-pentyl ether (ED50 of 380 μg g−1) showed considerable IGR activity, whereas 4′-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3′-buten-2′(E)-ketoxime-N-O-pentyl ether was found to be acutely toxic to larvae (ED50 of 268 μg g−1). Three compounds used in this study also were synergized by piperonyl butoxide. Synergis...
Published Version
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