Evaluation of strip meniscometry, tear meniscus height and depth in the diagnosis of dry eye disease in asian Indian eyes

Abstract

PurposeEvaluate role of Strip Meniscometry (SMT) and lower tear meniscus [height (LTMH) & depth (LTMD)] in diagnosis of Dry Eye Disease (DED) and its comparison with TBUT. MethodsIn a prospective observational cross-sectional study of 120 eyes [60 eyes of 30 DED (Group 1) & 60 eyes of 30 controls (Group 2)] TBUT, Schirmer's, SMT, LTMH and LTMD was done. Subjects >18 years diagnosed with DED (aqueous deficient) as per Tear film and Ocular surface society-Dry Eye Workshop (TFOS DEWS) II protocol and Ocular surface disease Index (OSDI) questionnaire, with no associated systemic risk factor and previous ocular medical/surgical treatment were included as cases and subjects with no history of ocular surface disease as controls. The data was analyzed using t-test & receiver operating characteristic curve. ResultsTBUT & Schirmer's values were significantly lower in group 1 (p < 0.05). SMT was 2.28 ± 1.28 (Range 0–6) & 8.11 ± 1.39 (Range 3–10) in group 1 & 2 respectively (p < 0.05). LTMH was 169.32 ± 29.84 μm (Range 85.78–209.11) and 234.41 ± 19.51 μm (Range 203.89–289.53) in Group 1 & 2 respectively (p < 0.05). LTMD was 144.32 ± 33.60 μm (Range 57.49–190.12) and 206.69 ± 14.17 μm (Range 187.12–251.50) in Group 1 & 2 respectively (p < 0.05). The SMT, LTMH and LTMD showed a cutoff value of < 5 mm (AUC 0.994, sensitivity 96.7%, specificity 96.7%), 204.96 μm (AUC 0.998, sensitivity 98.3%, specificity 96.7%) & 190 μm (AUC 0.995, sensitivity 96.7%, specificity 95%) respectively. ConclusionSMT, ASOCT, LTMD & LTMH are useful non invasive diagnostic tests for DED comparable with TBUT.