Evaluation of Stability of Complexes of Inner Transition Metal Ions with 2-Oxo-1-pyrrolidine Acetamide and Role of Systematic Errors

Sangita Sharma,Ketan Patel,Jayesh Ramani,Mahesh Kadiya,Dhara Patel

doi:10.1155/2011/147082

Abstract

BEST FIT models were used to study the complexation of inner transition metal ions like Y(III), La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Dy(III) and Th(IV) with 2-oxo-1-pyrrolidine acetamide at 30°C in 10%, 20, 30, 40, 50% and 60% v/v dioxane-water mixture at 0.2 M ionic strength. Irving Rossotti titration method was used to get titration data. Calculations were carried out with PKAS and BEST Fortran IV computer programs. The expected species like L, LH+, ML, ML2and ML(OH)3, were obtained with SPEPLOT. Stability of complexes has increased with increasing the dioxane content. The observed change in stability can be explained on the basis of electrostatic effects, non electrostatic effects, solvating power of solvent mixture, interaction between ions and interaction of ions with solvents. Effect of systematic errors like effect of dissolved carbon dioxide, concentration of alkali, concentration of acid, concentration of ligand and concentration of metal have also been explained here.

Highlights

BEST FIT models were used to study the complexation of inner transition metal ions like Y(III), La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Dy(III) and Th(IV) with 2-oxo-1-pyrrolidine acetamide at 30 0C in 10%, 20, 30, 40, 50% and 60% v/v dioxane-water mixture at 0.2 M ionic strength
We have carried out a study on binary complexes of inner transition metal ions with 2-oxo-1-pyrrolidine acetamide in solution state BEST FIT models of inner transition metal ions 2-oxo-1-pyrrolidine acetamide were developed in different v/v dioxane-water mixtures at 30±0.1 0C and ionic strength 0.2 M
It is anticipated that two 2-oxo-1-pyrrolidine acetamide are coordinated to inner transition metal ions

Summary

Introduction

2-Oxo-1-pyrrolidine is well known drug used as cure for many clinical problems like to increase cognation and memory, slowing down brain ageing, increase in blood flow and oxygen to brain, add to stroke recovery, dementia and dyslexia[1,2,3,4]. A number of studies are being carried out to study the stability of metal complexes in solution state[7,8,9,10,11]. Studies on inner transition metal complexes of 2-oxo-1-pyrrolidine acetamide in aqueous as well as in mixed equilibria are not reported. Effect of systematic errors on these complexes in solution state is not reported. We have carried out a study on binary complexes of inner transition metal ions with 2-oxo-1-pyrrolidine acetamide in solution state BEST FIT models of inner transition metal ions 2-oxo-1-pyrrolidine acetamide were developed in different v/v dioxane-water mixtures at 30±0.1 0C and ionic strength 0.2 M. The effects of variations in asymmetry potential, liquid junction potential, activity coefficient, sodium ion error and dissolved carbon dioxide on response of glass electrode were incorporated as correction factors[13]. High precision water bath Cat No MSW-274 with readability ±0.1 0C was used to maintain the temperature

Procedure

Results and Discussion

Conclusion