Abstract
Objective: It was aimed to compare the some tumor markers, acute phase proteins, sialic acid and lipid bound sialic acid levels in patients with stomach cancer before and after chemotherapy to the healthy controls. Material and Methods: Forty-eight patients with stomach adenocarcinoma and 20 healthy controls, totally 68 subjects were used. Blood samples were taken from all patients before and after chemotherapy and controls to analyse the levels of tumor markers (CA 125, CA 15-3, CA 19-9, CEA), acute phase proteins (CRP and fibrinogen) and SA (sialic acid), LSA (lipid bound sialic acid). Results: Before chemotherapy the serum levels of CA 125, CA 15-3, CA 19-9, CEA SA, LSA, CRP and fibrinogen (107.30 U/ml, 65.74 U/ml, 295.86 U/ml, 108.57 ng/ml, 199.60 mg/dl, 41.89 mg/dl, 86.03 mg/l and 469.42 mg/dl ) were higher than after chemotherapy group (36.46 U/ml, 34.00 U/ml, 100.18 U/ml, 20.20 ng/ml, 87.67 mg/dl, 31.06 mg/dl, 57.04 mg/l and 379.04 mg/dl) and the controls (8.64 U/ml, 21.65 U/ml, 21.52 U/ml, 2.77 ng/ml, 73.75 mg/dl, 27.47 mg/dl, 2.37 mg/l, 303.5 mg/dl). Conclusion: The serum levels of SA and LSA may be considered the indicators of poor/good prognosis of stomach cancer. CRP and fibrinogen are suggested as available biomarkers for diagnosis and prognosis in patients with stomach cancer.
Highlights
The prevalence of stomach cancer has shown differences among the countries
CRP and fibrinogen are suggested as available biomarkers for diagnosis and prognosis in patients with stomach cancer
While serum level of CA 125 was found as 107.30 U/ml before chemotherapy and diminished to 36.46 U/ml after chemotherapy
Summary
The prevalence of stomach cancer has shown differences among the countries. It is still in the second rank at the cancer deaths in the world despite the clear decrease in its prevalence. Because the stomach cancer is a insidious disease, it is difficult to understand its etiology, there are many studies on the biomarkers or tumor markers to support the diagnosis. Tumor markers which have different characteristics such as glycoprotein and glycolipid show specific features for many organ cancers. They help to diagnose the cancer and help to estimate the good and poor prognosis of the cancer patients. The qualitative or quantitative chemical, molecular biological or immunologic methods can be used for the diagnosis of cancer
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