Evaluation of some laboratory parameters in patients with chronic generalized periodontitis associated with persistent herpesvirus infection

Abstract

Introduction. The nature of local pathogenetic mechanisms of periodontal tissue lesions is the result of the interaction of various etiopathogenetical determinants. The researchers almost do not consider influence of persistent herpes virus infection on the state of immunobiological organism resistance and deterioration of the overall prognosis of dental disease. Aim. To identify the features of laboratory parameters in 45 patients with periodontal pathology associated with herpes virus infection. Material and methods. Laboratory study of 45 people with periodontal pathology associated with herpes virus infection (group I), 20 individuals with periodontal pathology without concomitant herpes infection (group II) and 10 individuals without periodontal pathology and without concomitant herpes viral infections (control group), namely: determining the amount of gingival fluid according to M. Barer et al. and determining therein the content of inflammatory mediators – histamine and serotonin according to B. Mykhailychenko, adsorption reaction of microorganisms was studied according to M. Danilevsky and T. Bilenchuk. Results. Amount of gingival fluid in persons of I and II groups had significant difference (p<0,05) between both among them and in comparison with the control group. The content of histamine and serotonin in the gingival fluid of individuals of I and II groups had significant difference (p<0,05) between them, it was also significantly (p<0,01) higher than the corresponding figures for patients of the control group. Indices of RAM-positive cells in patients of groups I and II were significantly lower (p<0,05) than in the control group. In addition, indices of group I were significantly lower (p <0,05) than in group II. Conclusions. Persistent herpes infection significantly affects the state of immunobiological organism resistance and worsens the overall prognosis of periodontal tissue pathology.