Abstract
Phialosimplex asmahalo is an obligate halophilic fungus that requires at least 5 % (w/v) sodium chloride for growth. It was previously isolated and identified. The ethyl acetate extract ofPhialosimplex asmahalo was fractionated and three compounds 1, 3, and 6 were purified. In this studypure compounds of Phialosimplex asmahalo were evaluated for their anti-diabetes, anti-inflammatory, antiviral and hepatoprotective activities. Compounds 3 and 6 have anti-diabetic activities with IC50 47.03 and 82.3 respectively; whereas compound 1 has no anti-diabetic activity. Compounds 3 and 6 have anti-inflammatory activities with IC50 125 and 294 respectively; whereas compound 1 has no anti-inflammatory activity. Compound 3 has antiviral activity against Hepatitis A virus and Herpes Simplex type 1 virus in a percentage of 24.7 and 10.2 respectively. Compound 6 has antiviral activity against Hepatitis A only with a percentage of 11.3. Compound 1 has no antiviral activity against Hepatitis A virus and Herpes Simplex type 1 virus. Compounds 1 and 3 have hepatoprotective activities percentage 7.1 and 23.6 respectively; whereas compound 6 has no hepatoprotective activity.
Highlights
Halophiles are organisms represented by archaea, bacteria, and eukarya for which the main characteristic is their salinity requirement, halophilic “salt-loving”
The general features of halophilic microorganisms are the low nutritional requirements and resistance to high concentrations of salt with the capacity to balance the osmotic pressure of the environment (Ventosa et al, 1998)
The discovery of new compounds from halophilic and halotolerant microorganisms has become increasingly important in natural products research (Quadri et al, 2016; Chen et al, 2010; Mazguene et al, 2018; Chen et al, 2019; Tang et al, 2019) as these microorganisms represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures (Karthikeyan et al, 2018)
Summary
Halophiles are organisms represented by archaea, bacteria, and eukarya for which the main characteristic is their salinity requirement, halophilic “salt-loving”. Halophiles are the best source of producing bioactive compounds as low water activity induces the production of secondary metabolites (Sepcic et al, 2010). MATERIALS AND METHODS Organism: Phialosimplex asmahalo was previously isolated, identified and its ethyl acetate extract was fractionated to obtain purified active compounds.
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