Abstract
The present study aims to detect several biochemical markers associated with PCOS (Polycysticovary syndrome) in Iraqi women comparing the results with control normal fertile women andalso studying the effect of obesity on the same biochemical markers. Ninety eight women withPCOS, 51 non-obese [body mass index (BMI) less than 25 kg/m2] and 47 obese (BMI >25 kg/m2)were enrolled for the study. Each group of them was compared forty normal fertile women ascontrol group matched for each in age and BMI. The first part of this study was devoted to themeasurement of Body Mass Index (BMI) and Waist Hip Ratio (WHR), subdivided PCOSaccording to the body mass index, and measurement of fasting insulin, fasting glucose,Homeostatic Model Assessment (HOMA), HbA1c and lipid profile. A significant differences wasfound in HbA1c (P≤0.0001) VLDL (p≤0.0001), triglyceride (p≤0.05) and cholesterol (p≤0.05)between obeses and lean PCOS patients. Insulin serum level (P≤0.0001) was highly significantlyincreased in obeses PCOS patients as compared to obeses control, the serum insulin (P≤0.0001)also significantly increased in lean PCOS women when compared with lean control. There was asignificant differences between HOMA (P≤0.05) in obeses PCOS patients than in the obesecontrol group and between obese and lean women PCOS patients.
Highlights
Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women of reproductive age with a prevalence of 6.6–6.8%[1]
PCOS affects 6–10% of women according to 1990 NIH criteria [14,15] or 6.6–6.8% [1], and even more individuals according to the broader Rotterdam criteria [5], which makes it one of the most common human disorders and the single most common endocrinopathy in women of reproductive age
Aim of study The present study aims to detect several biochemical markers associated with PCOS(Polycystic ovary syndrome ) in Iraqi women comparing the results with control normal fertile women and studying the effect of obesity on the same biochemical markers
Summary
Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women of reproductive age with a prevalence of 6.6–6.8%[1]. Obesity impairs human reproduction by reducing pregnancy chances and increasing miscarriage rates and obstetric complications for both mother and fetus, leading to reduced live birth rates This effect seems to occur in all types of conception [17]. Aim of study The present study aims to detect several biochemical markers associated with PCOS(Polycystic ovary syndrome ) in Iraqi women comparing the results with control normal fertile women and studying the effect of obesity on the same biochemical markers. The mean age (mean±SD) of obeses and lean polycystic ovarian syndrome patients were (28.11±4.99, and 27.50±4.24 respectively) ranging from 20 to 35 years while that of obeses and lean control were (27.50±4.24, 28.25±3.89 respectively) ranging from 20 to 37 years with no significant differences between these groups (p≤0.05). The primary infertility is 63.8% and 58.8% in obeses PCOS and lean patients, respectively .Whereas, the percentage of secondary infertility were 36.2% and 41.2% respectively with no significant differences between these groups
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