Abstract
Abstract Objectives: To compare the laboratory and clinical out‐come of patients who received solvent/detergent‐treated plasma (SDP) and fresh‐frozen plasma (FFP). Methods: A randomized, double‐blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT to ≤ 15 s in patients with acquired coagulation deficits. Results: 45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to ≤ 15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP). Conclusion: No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.
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