Abstract
BackgroundThe target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol.MethodsThe current study aimed at evaluating the difference between target concentrations of propofol and performance, which was measured using the SLOG/TCI-III system in children. Thirty children fulfilling the I-II criteria according to American Society of Anesthesiology were enrolled in the study. The target plasma concentration of propofol was fed into the SLOG/TCI-III system and compared with the measured concentrations of propofol. Blood samples were collected and analyzed by high performance liquid chromatography with fluorescence detector. The performance error (PE) was determined for each measured blood propofol concentration. The performances of the TCI-III system were determined by the median performance error (MDPE), the median absolute performance error (MDAPE), and Wobble (the median absolute deviation of each PE from the MDPE), respectively.ResultsConcentration against target concentration showed good linear correlation: concentration = 1.3428 target concentration - 0.2633 (r = 0.8667). The MDPE and MDAPE of the pediatric system were 10 and 22%, respectively, and the median value for Wobble was 24%. MDPE and MDAPE were less than 15 and 30%, respectively.ConclusionsThe performance of TCI-III system seems to be in the accepted limits for clinical practice in children.
Highlights
The effectiveness and safety of pharmacokinetics and pharmacodynamics of anesthetic drugs, such as propofol, were studies in the pediatric population
The performance of target controlled infusion (TCI)-III system seems to be in the accepted limits for clinical practice in children
Clinical studies on TCI of propofol for pediatric anesthetization have verified that factors such as ethnic group, body weight, and age influence pharmacokinetic parameters, which can vary greatly from those of adults [1,2,3]
Summary
The effectiveness and safety of pharmacokinetics and pharmacodynamics of anesthetic drugs, such as propofol, were studies in the pediatric population. Clinical studies on TCI of propofol for pediatric anesthetization have verified that factors such as ethnic group, body weight, and age influence pharmacokinetic parameters, which can vary greatly from those of adults [1,2,3]. As the Diprifusor software was written based on adult parameters, Absalom et al pointed out that the adult parameters of Marsh model might not be appropriate for TCI of propofol in children [4]. This challenge was emphasized in TCI of propofol to children in pediatric anesthetization [5]. The target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol
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