Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO).

Abstract

While extracorporeal membrane oxygenation (ECMO) is a valuable therapy for patients with lung or heart failure, clinical use of ECMO remains limited due to hemocompatibility concerns with pro-coagulatory hollow fiber membrane geometries. Previously, we demonstrated the feasibility of silicon nanopore (SNM) and micropore (SμM) membranes for transport between two liquid-phase compartments in blood-contacting devices. Herein, we investigate various pore sizes of SNM and SμM membranes - alone or with a polydimethylsiloxane (PDMS) protective coating - for parameters that determine suitability for gas exchange. We characterized the bubble or rupture point of these membranes to determine sweep gas pressures at which gas emboli would form. The smallest pore size SNM and the SμM with PDMS coating could be pressurized in excess of 260 cmHg without rupture, which is comparable to hollow fiber sweep gas pressures. Oxygen flux for the SμM with and without PDMS was insignificantly different at 0.0306 ± 0.0028 and 0.0297 ± 0.0012mL/min, respectively, while SNM flux was significantly lower at 0.0149 ± 0.0040mL/min. However, the area-normalized mass transfer coefficient of the SNM was 338 ± 54mL O2 m-2min-1 cmHg-1 - an order of magnitude higher than that of the SμM with and without PDMS (57.3 ± 5.5 and 55.6 ± 2.2mL O2 m-2min-1 cmHg-1). Ultimately, we conclude that SμM-PDMS may make effective membranes for ECMO, since they are both mechanically robust and capable of high oxygen flux.