Abstract
The Sudanese population has high rate of coronary artery disease (CAD). The potential association between deficiency of vitamin B12 and folic acid, in patients with acute myocardial infarction (AMI), where investigated previously with conflicted results. A case-control study was carried out involving 60 AMI patients (age 39–87 years; 40 men and 20 women) and 40 normal healthy individuals (age 39–84 years; 20 men and 20 women). Fasting venous blood samples were obtained from patients and controls. Serum was analyzed for vitamin B12 and folic acid using radio assays. The mean concentration of serum B12 and folate in AMI patients were found to be significantly lower than in controls. Vitamin B12 and folate deficiency may be considered as a risk factor for CAD development.
Highlights
Cardiovascular disease (CVD) is the leading cause of death in both developed and developing countries
More recent reports have shown an association between the deficiencies of vitamin B12 and, folic acid known as a risk factor for myocardial infarction[2].This has focused attention on vitamin B12 and folate and the important role they might play in protection against the development of coronary artery disease (CAD)[3]
The result of vit B12 and folic acid with age of case and control was found significant significant in folic acid case and control group with p.value(0.003) & (0.14) respectively .These finding in the present study showed that the negative correlation between folic acid in all ages, since the degree of correlation between CAD and vitamin B12 and folate deficiencies in all ages may differ from population to population depending on genetic factors and gene environment interaction
Summary
Cardiovascular disease (CVD) is the leading cause of death in both developed and developing countries. A number of studies during the past few years have indicated a protective role of vitamin B12 and folate against the development of CAD[1]. More recent reports have shown an association between the deficiencies of vitamin B12 and, folic acid known as a risk factor for myocardial infarction[2].This has focused attention on vitamin B12 and folate and the important role they might play in protection against the development of CAD[3]. Folic acid is a B vitamin which is vital for the formation of red blood cells. Together with vitamin B12, is necessary to form red blood cells. PA was a fatal illness before the 1920s This changed after Whipple suggested raw liver as a treatment, Those vitamins help nerves to function properly[8]. Folic acid is essential in the formation of DNA (genetic material) within everybody cell, allowing each cell to replicate perfectly[9]
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