Evaluation of serum resistin in children with chronic renal failure

Abstract

Objective To evaluate the serum level of resistin in kids with persistent renal failure and correlation with other medical and laboratory parameters. Background Serum resistin is elevated in chronic renal failure due to a reduced renal clearance and there may be an inverse correlation between resistin and renal characteristic. Patients and methods This study was carried out as a case–control study and included 96 children aged from 6 to 18 years (34 undergoing hemodialysis and 30 on conservative remedy) and 32 apparently healthy kids who constituted the control group, who were recruited from the pediatric hemodialysis unit of Menoufia University Health Facility, Egypt, from May 2017 to April 2018. Complete blood count and electrolytes have been measured before hemodialysis; however, serum resistin was measured before and after hemodialysis in kids with persistent renal failure. Results A highly significant increase in resistin level in the case groups and the control group. This highly significant difference found in the resistin level differed according to the chronic kidney disease stage of progression as the hemodialysis patients have higher resistin levels than patients on conservative treatment. There was a highly significant decrease in resistin level after hemodialysis session than before. Conclusion Patients with chronic renal failure had higher serum resistin levels than the control group and it was found that resistin levels were more elevated in hemodialysis patients than patients on conservative treatment. So, it could be considered as a new diagnostic marker in chronic renal failure and serum resistin levels are reduced by hemodialysis treatment.