Abstract
BackgroundProstate cancer (PCa) and benign prostatic hyperplasia (BPH) are diseases of elderly men and are related to increased oxidative stress (OS). Although prolidase has a role in collagen metabolism, it is also used to evaluate OS in many diseases. However, there is a lack of data about serum prolidase activity (SPA) in prostate cancer. The aim of this study was to evaluate and compare SPA levels in males with BPH and PCa.MethodsEvaluation was made of a total of 81 men who underwent transrectal ultrasound guided prostate biopsy for a definitive diagnosis due to high PSA levels. Patients were separated into 2 groups as BPH and PCa patients. Pre-biopsy malondialdehyde (MDA), superoxide dismutase (SOD), PSA levels and serum prolidase activities (SPA) were compared between the groups and the correlations of SPA with the other parameters were also investigated in both groups.ResultsBPH was diagnosed in 51 patients and PCa in 30. The mean age of patients was similar in both groups as 63.25 ± 5.81 years in the BPH group 65.30 ± 7.35 years in the PCa group(p:0.081). The median MDA and SOD levels were insignificantly increased in the PCa patients. SPA values were similar in BPH and PCa patients. SPA did not correlate with age, PSA, MDA or SOD levels in either group.ConclusionsOur study results revealed that serum prolidase activity is similar in BPH and PCa cases and is not correlated with MDA, SOD or PSA levels.
Highlights
Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are diseases of elderly men and are related to increased oxidative stress (OS)
Informed consent was obtained from each participant and the study protocol was approved by the Clinical ResearchEthics Committee of Kahramanmaras Sutcu Imam University (2016/ 20–257)
The results of the current study revealed that serum prolidase activity was reduced in PCa patients when compared to the BPH group, the difference was not statistically significant
Summary
Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are diseases of elderly men and are related to increased oxidative stress (OS). The aim of this study was to evaluate and compare SPA levels in males with BPH and PCa. Prostate cancer (PCa) is the most common non- skin cancer and one of the main reasons for cancer- specific deaths in men [1]. Benign prostatic hyperplasia (BPH) is a progressive disorder that develops secondary to increased proliferation of stromal and glandular cells, with a predominance of mesencyhmal cells [3]. PCa and BPH are the leading urological problems of aging men and manifest with disturbing obstructive and irritative symptoms. In addition to androgen and age dependence, oxidative stress, infection and inflammation are the other accepted predisposing factors for BPH and PCa [6, 7]
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