Abstract
Background & Objective:The aim of this study was to measure serum pentraxin 3 (PTX3) in patients with acute myocardial infarction (MI) and compare it with the control group.Methods:In this case-control study, 60 patients with MI (±ST-segment elevation) were included in the case group , and those with symptoms suspicious for coronary artery disease (CAD) and with no abnormal findings in angiography and troponin I level less than 99th percentile of normal population were included as a control group (N=30). Serum PTX3 and troponin I were measured.Results: In this study, 60 patients including 34 men and 26 women were included in the case group (mean age: 61.4±8.86 years in non–ST-segment elevation myocardial infarction [NSTEMI] subgroup and mean age: 57.9±9.49 years in ST-segment elevation myocardial infarction [STEMI] subgroup), as well as 13 men and 17 women as the control group (mean age: 55.47±10.09 years). PTX3 level was higher in MI cases (1128.4±1205 pg/mL) compared to controls (394.5±170.40 pg/mL) (P=0.001). There was no relationship between ejection fraction (EF) and PTX3 level in the MI group. The area under the ROC curve (AUC) of PTX3 in MI was presented by 0.828 (AUC=0.828) (P>0.001). We defined three different cutoffs for PTX in this study, in which the cutoff ≥400 pg/mL had the highest sensitivity (92%), and the cutoff ≥700 pg/mL had the highest specificity (97%). Conclusion:According to the results of this study, PTX3 as an inflammatory marker showed higher level in patients with MI, especially in STEMI cases. Therefore, combined evaluation of troponin I and PTX3 levels would be associated with more accuracy in diagnosis of MI.
Highlights
Cardiovascular diseases (CVDs) are among the most common causes of mortality and morbidity all over the world
Previous studies have suggested that different factors are responsible for CVD etiology [1]; some pieces of evidence showed that inflammation makes atherosclerotic lesions prone to the erosion and rupture [1]
In this case-control study, a total of 60 patients (34 men and 26 women) with coronary artery disease (CAD) were enrolled, who were referred to Ayatollah Rohani Hospital; Babol, Iran, 30 control subjects were included in the control group
Summary
Cardiovascular diseases (CVDs) are among the most common causes of mortality and morbidity all over the world. Previous studies have suggested that different factors (such as age, gender, diabetes mellitus, hyperlipidemia, and hypertension) are responsible for CVD etiology [1]; some pieces of evidence showed that inflammation makes atherosclerotic lesions prone to the erosion and rupture [1]. In the pentraxin (PTX) family, in addition to Creactive protein (CRP), PTX3 (defined as a long PTX) is locally secreted by smooth muscle and endothelial cells or by monocytes/macrophages exposed to the first inflammatory signals The aim of this study was to measure serum pentraxin 3 (PTX3) in patients with acute myocardial infarction (MI) and compare it with the control group
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
