Evaluation of Serum Magnesium Levels in Patients With the Diagnosis of Depressive Disorder Applied to a Psychiatry Clinic: A Retrospective Study

Abstract

Objective: The role of magnesium in the pathophysiology of depression has increased the interest in magnesium. However, contradictory results regarding whether the magnesium levels decrease in depression are reported in the literature. Therefore, in this study, we aimed to evaluate serum magnesium levels in patients diagnosed with depressive disorder who applied to the psychiatry outpatient clinic Materials and Methods: The data of 1013 patients who were diagnosed with depressive disorder and whose serum magnesium levels were measured were included in the study by retrospectively scanning the data of the patients who had applied to the Psychiatry outpatient clinic of Balıkesir University Faculty of Medicine between July 2020 and July 2022. Since the serum glucose, GGT and creatinine values were above their reference ranges in 183 of 1013 patients included in the study, the data of these patients were excluded from the analysis. Results: Serum magnesium values of 12.9% of female and 9.1% of male patients were below the reference values (1.9-2.7 mg/dl). Total mean ( ±SD) magnesium value was statistically significantly different from those of female and male patient groups ( 2.02±0.15 mg/dl vs 2.01±0.16 mg/dl and 2.04±0.15 mg/dl, and P