Abstract
International Journal of Medicine and Public Health,2014,4,1,107-109.DOI:10.4103/2230-8598.127169Published:january/2014Type:Original ArticleEvaluation of serum lipoprotein (a) in young patients with myocardial infarctionChandrakant Pragjibhai Kamariya, Jignesh H. Gorasia, Uday Vachhani, and Mukesh Gohel Chandrakant Pragjibhai Kamariya, Jignesh H. Gorasia, Uday Vachhani, Mukesh Gohel Department of Biochemistry, Pandit Deendayal Upadhyay Medical College, Rajkot, Gujarat, India Abstract:Context: Indians are prone as a community to coronary artery disease (CAD) at a much younger age. CAD is affecting Indians 5-10 years earlier than other communities. Lipoprotein (a) (Lp (a)) is now recognized as an independent risk factor for CAD. It is a genetic risk factor. Aim: We evaluate the Lp (a) in young patients with myocardial infarction (MI). Settings and design: Study population consisted of 50 patients having MI and 50 control groups. Subjects and Methods: Fasting samples were collected from patients and were analyzed for Lp (a), lipid profile, and blood sugar on fully automated analyzer. Statistical analysis used: Statistical analysis is carried out by using Student’s t-test. Results: The difference in total cholesterol (P = 0.8192), high density lipoprotein-cholesterol (HDL-C) (P = 0.11), low density lipoprotein-cholesterol (LDL-C) (P = 0.8143), triglyceride (P = 0.1177) levels, and total cholesterol/HDLcholesterol ratio (P = 0.2129) were observed between the case and control groups in this study was not statistically significant. The difference in the Lp (a) levels between the case and control groups was highly significant (P-value = 0.0001). Conclusions: This study demonstrated that in young patients with MI there was a male predominance. Lp (a) level is an important and independent risk factor for CAD. Serum Lp (a) level is not dependent on serum total cholesterol level. Keywords:Coronary artery disease, Lipid profile, Lipoprotein (a)View:PDF (355.26 KB)
Highlights
Context: Indians are prone as a community to coronary artery disease (CAD) at a much younger age
Developing countries, especially like India are on the verge of twin epidemics of communicable and noncommunicable diseases namely hypertension and coronary artery disease (CAD)
The prevalence of CAD is high amongst Indians; 2.2 to five times for myocardial infarction (MI) and 1.5 to three times for CAD mortality
Summary
Context: Indians are prone as a community to coronary artery disease (CAD) at a much younger age. Lipoprotein (a) (Lp (a)) is recognized as an independent risk factor for CAD. Results: The difference in total cholesterol (P = 0.8192), high density lipoprotein-cholesterol (HDL-C) (P = 0.11), low density lipoprotein-cholesterol (LDL-C) (P = 0.8143), triglyceride (P = 0.1177) levels, and total cholesterol/HDLcholesterol ratio (P = 0.2129) were observed between the case and control groups in this study was not statistically significant. The prevalence of CAD is high amongst Indians; 2.2 to five times for myocardial infarction (MI) and 1.5 to three times for CAD mortality. The overall age standardized mortality ratio of CAD in Asian males compared to whites was 37.3% higher in age group of 20-29 years, compared to 36% higher at all ages in the UK. The prevalence of CAD is three-fold higher in south India in comparison to north India
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