Evaluation of Serum Leptin Level in Correlation with CRP in a Sample of Iraqi Patients with Inflammatory Bowel Disease at Gastroenterology and Hepatology Teaching Hospital

Abstract

Introduction: adipocytokines display avital role in inflammation and metabolism, body metabolism changes in inflammatory bowel disease (IBD) and chronic inflammation conceder the pathognomonic of this disease, s. leptin and C-Reactive protein (CRP( in patients with active disease either Crohn disease or ulcerative colitis. The aim of this descriptive study is to evaluate the serum leptin and CRP level in a sample of Iraqi patients with IBD of variable disease activity index. METHOD: serum concentration of leptin was studied in 79 patients diagnosed as IBD [41 patients diagnosed as Crohn’s disease (CD) and in 38 patients diagnosed as ulcerative colitis (UC)]. The diagnosis based on colonoscopy, CT, MRI, US and histopathological examination of mucosa. Serum leptin and CRP was measured by an indirect ELISA. Leptin level was compared with CRP and correlated with disease activity. RESULTS: data showed that out of 38 patients diagnosed as UC, 10 (26.3%) were in remission, 22 (57.9%) were in moderate activity, and 6 (15.8%) have severely active disease. On the other hand, out of 41 patients diagnosed as CD, 17 (41.5%) were in remission state, 20 (48.8 %) have moderate active disease, and 4 (9.8%) have severely active form. Serum leptin in the UC group was significantly associated with disease activity in an inverse pattern (p = 0.045), while no significant association between action index in patients with Crohn disease and leptin level P-value = 0.77. While CPR level have significant association with ulcerative colitis patients P-value = 0.017 and with Crohn disease P-value = 0.043.Comparing both CRP and leptin level showed significant association with UC as an overall effect and those in decrease only (P-value = 0.047, 0.029 correspondingly), while this association was only significant as an overall effect for CD group P-value = 0.043. conclusion: a significant association between disease activity in UC and CD with serum CRP. Comparing both CRP and leptin level showed that there is an overall significant association with both UC and CD, but not useful for defining their activity index.