Evaluation of Serum Leptin, Interlukein–6 and some Biochemical Parameters in Iraq obese Adult Patients

Abstract

Objective: The current study conducted for evaluating serum level of interleukin-6 and leptin (IL- 6) among Iraqi obese adult people and other biochemical parameters related with obesity. Methods: Leptin and IL-6 Levels were assessed in serum samples from 43 Iraqi obese adults and 30 non-obese healthy subjects. Results: Significant elevation (p<0.05) in S.Ca+ levels for obese females as compared to obese males and there is high decrease of significant (p<0.0001) in the S. Ca+ level for obese male as compared to control male. The liver function enzymes S. GOT S. GPT levels showed significant elevation (p<0.0001 and p<0.01) in obese female in comparison to their control and a significant elevation appeared at level of cholesterol for both (p<0.001 in male) and (p<0.01 in female), S LDL p<0.05 for obese male and HDL p<0.0001 in obese female. Finally, High positive correlation (p<0.01) between serum leptin levels for obese subjects and their BMI. Also, IL-6 revealed strong positive correlation (p<0.01) with S. TRIG and S. VLDL. Whereas, S.CREAT was positive association at level (p<0.05). Conclusions: The data revealed effect the obesity in different human body function, liver enzyme, lipid profile and leptin in adult’s male in different criteria according to the gender. As well as, the positive correlation between IL-6 with (S. CREAT, S. TRIG and VLDL) and leptin with BMI. Increased creatinine related with presence of inflammation or injury to the kidney, which was evidenced by the presence of a positive correlation with IL-6. Obesity effects on lipid profile and liver enzyme and leptin due to the sex hormone differences.