Evaluation of Serum Ischemia Modified Albumin Level in Male Patients with Androgenetic Alopecia

Abstract

Male pattern androgenetic alopecia (AGA) is associated with oxidative stress. Ischemia modified albumin (IMA) is albumin due to albumin modification caused by reactive oxygen species which occur during ischemia.to evaluate IMA levels in AGA patients and compare their levels in healthy control. The four study groups were group (A) included thirty obese patients with AGA, (B) included thirty non-obese patients with AGA, group (C) included ten obese normal volunteer and group (D) ten non obese normal volunteer. The AGA severity was calculated according to the modified Norwood Hamilton classification and serum IMA was measured by ELISA in all participants.The patients and control groups showed a non-significant difference as regards age, smoking and BMI. There was a significant difference between patients and control groups as regards the IMA levels (P= <0.0001). The IMA level showed a significant difference between obese patients and obese control (P= <0.0001), between non-obese patients and non-obese control (P <0.0001), between obese patients and non-obese patients (P < 0.0001), while it showed a non-significant difference between obese and non-obese control (P= 0.7776).The current study suggested that IMA levels were increased by the effect of obesity, but the AGA has an adding effect. The IMA levels showed a positive correlation with AGA duration and AGA severity. The IMA approved as diagnostic indicator of myocardial ischemia and elevated IMA were reported in metabolic syndrome, cardiovascular risk and obesity, and IMA might confirm the link between AGA and these metabolic disorders.