Evaluation of serum irisin level in patients with chronic kidney disease

Abstract

Background Energy imbalance is common among patients with end-stage renal disease. Altered circulating irisin level may occur in patients with end-stage renal disease and result in energy dysfunction. Aim To estimate serum irisin level as a diagnostic marker for the protein-energy wasting syndrome in patients with chronic kidney disease (CKD) and its relation with glomerular filtration rate. Patients and methods This is a case–control study. It was carried out at Internal Medicine Department of Al-Zahraa University Hospital and Damanhur Fever Hospital from March 2018 to March 2020. This study included 85 participants, and their age ranged between 20 and 50 years. There were 31 males and 54 females. A total of 55 patients with CKD irrespective of cause were classified according to estimated-glomerular filtration rate into 36 patients with stage III CKD and 19 patients with stage IV CKD, and 30 patients were included as a control group. Serum irisin concentration and the levels of hemoglobin, urea, creatinine, uric acid, albumin/creatinine (A/C) ratio, estimated-glomerular filtration rate, lipid profile, calcium, phosphate, sodium, potassium, and anthropometric measurement were measured. Results This study did not find a positive or negative correlation between serum irisin level and BMI in the case group, and skeletal muscle mass adjusted for fat area was not correlated with serum irisin concentration. Conclusion Irisin could not be used as a diagnostic marker for protein-energy wasting syndrome in patients with CKD.