Abstract
Aim: Chronic periodontal disease (CPD) and type 2 diabetes mellitus (T2DM) share common pathogenic pathways. This study was aimed to estimate levels the of serum interleukin (IL?10), an anti?inflammatory cytokine also associated with T2DM and evaluate its association with hyperglycemia.
 Materials and Methods: This investigation involved seventy five participants (55 males, 20 females, 30-55 age group) divided into three groups comprising 25 participants each: Group 1 (healthy controls), Group 2 (CPD patients) and Group 3 (T2DM patients with CPD) . Plaque index, gingival index, probing pocket depths (PPD), clinical attachment loss, bleeding on probing, random blood sugar, glycosylated hemoglobin (HbA1c), and serum IL?10 was measured.
 Results: Interleukin?10 was detected in all three groups. Statistically significant (P < 0.05) differences were observed in most of the variables in all groups. IL?10 correlated significantly with PPD in Group 1 and with HbA1c in Group 3. IL?10 levels were lowest in Group 2.
 Conclusion: Low IL?10 levels associated with high HbA1c. Pathogenic mechanisms of CPD seem to regulate IL?10. Serum IL?10 levels may be one of the predictors of hyperglycemia.
 Key words: Chronic periodontitis, diabetes mellitus, glycosylated, hemoglobin A, interleukin?10, type 2 diabetes mellitus
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