Abstract
Background and aim Management of chronic hepatitis B (CHB) infection is challenging owing to its wide immunologic phases and pathologic patterns. Quantification of serum HBs-Ag (qHBsAg) has been used as a mirror of intrahepatic viral replication, and therefore, its kinetics in these patterns may reflect diseases severity and hence may help in tailoring the management plan. So, this study was designed to assess the patterns and kinetics of qHBsAg among Egyptian patients presented with different forms of CHB. Patients and methods Between December 2016 and December 2017, patients with CHB were enrolled and categorized into three groups. Group I included naive aviremic patients [those with negative hepatitis B virus (HBV)-DNA-PCR without treatment]. Group II included naive low viremic patients (those with HBV-DNA-PCR Results A total of 90 patients were enrolled, with 30 patients in each group. In group I, qHBsAg and ALT levels exhibited relatively stable detectable positively correlated levels from W0 to W24. In group II, qHBsAg and ALT levels were the same as group I. In group III, qHBsAg, ALT levels, and HBV-DNA exhibited a significant decrease during the follow-up with the use of nucleotide analog therapy. Conclusion qHBsAg measurement, which is a cheap and easy test, can replace HBV-DNA and may help in reflection of disease activity and assessment of follow-up.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
