Evaluation of Serum Fetuin A in Psoriatic Patients and Its Correlation to Coronary Artery Disease

Abstract

Abstract Background Psoriasis is a chronic, immune-mediated, inflammatory disease of the skin. It is a multifactorial disease with genetic background triggered by environmental factors and immunological mediators. Fetuin A is considered as a marker to detect cardiac risk. Aim of the work to evaluate Fetuin A level in psoriatic patients and its correlation to coronary artery calcification and cardiovascular risks. Methods This is a case control comparative study was conducted at Dermatology outpatient clinic, during the period from January 2019 to November 2019. The Forty eight patients who were recruited in this study were classified to two groups, Group A (cases group): included twenty four patients presented clinically with chronic generalized psoriasis randomly selected from Dermatology outpatient clinics of Ain Shams University Hospital. Group B (control group): included twenty four age and sex matched healthy volunteers who were nonsmokers, non-alcoholics and don’t suffer any systemic or organic illness. Results Our results showed no significant correlation between levels of Fetuin A and age, sex, BMI or serum levels of TG or total cholesterol among psoriatic patients. In addition, negative correlation was found between Fetuin A and calcium scoring CT scan where the median serum plasma level of Fetuin A was found to be significantly decreased in cases with plaque psoriasis with increasing calcium score, with p-value < 0.001 and r = -0.928. Also, there is no significant correlation was found between levels of calcium scoring and age, sex, BMI or serum levels of TG or total cholesterol nor PASI scoring among psoriatic patients. Conclusion Fetuin A and Ca scoring CT scan appear to be a useful, simple, and noninvasive examination to investigate the presence of subclinical calcification in coronary blood vessel even in psoriatic patients who seem to be otherwise healthy.