Abstract
Objective: Parkinson’s disease (PD) is the second most common neurodegenerative disease. During PD many disorders occur in the neuroendocrine mechanism along with autonomic dysfunction. The aim of this study was to evaluate the values of cortisol and dehydroepiandrosterone sulphate (DHEAS) in idiopathic PD patients with postural instability (PI) in the medium and advanced stages of the disease. Methods: Three groups were included in this study; patients with PI, patients without PI and control subjects. Each of the groups consisted of 30 patients. The fasting serum cortisol and DHEAS values of patients were obtained. Results: Serum cortisol levels were significantly higher in patients with PI in the advanced stage of PD, whereas DHEAS levels were significantly higher in patients without PI in the early stage. Conclusion: This situation was evaluated as the reflection of neuroendocrine response that occurred secondary to the progressive advancing neurodegeneration seen in PD patients. The data obtained may contribute to a better understanding of the pathophysiology of PD that in intermediate and advanced stages. In addition, our findings may help in establishing new treatment options for PD patients in the future.
Highlights
Parkinson’s disease (PD) has a chronic neurodegenerative and progressive period
The aim of this study is to evaluate serum cortisol and dehydroepiandrosterone sulphate (DHEAS) values in idiopathic PD patients who have postural instability (PI) (Hoehn&Yahr stage 3-4) and who do not have PI (Hoehn&Yahr stage 1-2) by comparing them with a healthy group
Serum cortisol was found as 16.54 μg/dl in the group with PI (Hoehn&Yahr stage 3-4), as 11.69 μg/ dl in the group without PI (Hoehn&Yahr stage 1-2) and as 10.13 μg/dl in the control group
Summary
Parkinson’s disease (PD) has a chronic neurodegenerative and progressive period. During PD, in addition to common autonomic dysfunction, many changes occur in the neuroendocrine mechanism including circadian rhythm in the dopaminergic system of the central nervous system (CNS) [1].Gültekin M, et al Serum cortisol and DHEAS levels in parkinsonPostural instability (PI) generally shows an increase towards the chronic stage of the disease and affects daily life negatively by preventing patients from the having independent motor skills. Parkinson’s disease (PD) has a chronic neurodegenerative and progressive period. Gültekin M, et al Serum cortisol and DHEAS levels in parkinson. Postural instability (PI) generally shows an increase towards the chronic stage of the disease and affects daily life negatively by preventing patients from the having independent motor skills. Cortisol and dehydroepiandrosterone (DHEA) are steroid type hormones that significantly affect energy metabolism, the immune system and stages of ageing. The importance of dehydroepiandrosterone sulphate, which is an esterified form of DHEA, has been identified in the elderly population, it’s the physiologic effects have not been explained clearly yet. Consistent with this, a few studies have been conducted on neurodegenerative diseases and changes in the levels of neurosteroids to determine if there is an association among them [3]
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