Abstract
Objective:The aim of the study was to assess serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.Materials and Methods:One hundred forty pregnant women were enrolled in the study, of which 100 subjects were preeclamptic and 40 were healthy controls. Serum concentrations of cathepsin B, D, and L were measured and compared between the preeclamptic and control groups.Results:Cathepsin B and D concentrations were significantly higher in the preeclamptic group compared with the control group. There was no statistically significant difference between the groups in terms of cathepsin L concentrations. Cathepsin B concentrations were significantly higher in women with preeclampsia with severe features compared with those with preeclampsia alone.Conclusion:Women with late-onset preeclampsia have significantly higher serum cathepsin B and D concentrations than controls. Cathepsin B and D may be promising biomarkers in women with late-onset preeclampsia.
Highlights
Cathepsin proteases have been suggested to be involved in a variety of cellular processes such as apoptosis, angiogenesis, cell proliferation, and invasion[1]
Cathepsin B concentrations were significantly higher in the preeclamptic group compared with the control group (4.24±3.51 ng/mL vs. 2.04±1.97 ng/mL, respectively; p
Cathepsin D concentrations were significantly higher in the preeclamptic group compared with the control group (4.97±1.24 ng/mL vs. 4.20±1.65 ng/mL, respectively; p
Summary
Cathepsin proteases have been suggested to be involved in a variety of cellular processes such as apoptosis, angiogenesis, cell proliferation, and invasion[1]. The important roles of cathepsins have been implicated in normal and abnormal placentation;(1) research on the serum concentrations of cathepsins in preeclampsia is limited. Preeclampsia is one of the leading causes of maternal-fetal morbidity and mortality, affecting approximately 3-5% of all pregnancies[2]. Determining late-onset preeclampsia, which is more common than the early-onset preeclampsia,(2) and identification of high risk individuals may be helpful for close monitoring and to minimize adverse outcomes in clinical practice. The aim of the study was to assess serum. PRECIS: Cathepsin B and D may be promising biomarkers in women with late-onset preeclampsia. Presented: As a poster at the FMF World Congress, 17th World Congress in Fetal Medicine; June 2018, Athens, Greece
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Turkish Society of Obstetric and Gynecology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
