Evaluation of serum calcium and serum parathyroid levels in post-menopausal women with and without oral dryness.

Abstract

The primary objective of this study was to estimate and secondary objective was to compare the serum calcium levels and serum parathyroid hormone (PTH) levels in post-menopausal women with and without oral dryness (OD). A case-control study was carried out on 80 selected post-menopausal women. Salivary flow was assessed by flow rate; serum calcium concentrations were assessed through Semi Autoanalyzer by Arsenazo III reaction. The serum PTH concentration was measured by the enzyme-linked immunosorbent assay. Severity of OD was assessed by a questionnaire through which the xerostomia inventory (XI) score could be measured. Statistical analysis of Student's t-test, Mann-Whitney test and Pearson's correlation was used. There was a significant difference in mean values of both serum PTH concentration and XI score in post-menopausal women with/without OD (p < 0.001). No statistically significant difference (p = 0.354) was found in salivary flow rate and serum calcium levels in post-menopausal women in both groups. A positive correlation was found between the serum PTH and XI score in both case and control groups (p < 0.05). Severity of oral dryness in post-menopausal women is associated with the high levels of serum PTH. However, the correlation of severity of OD with serum calcium could not be established.