Abstract
The immune response to Pseudomonas aeruginosa strains could be influenced by differences in antibiotic resistance and virulence. At the present time, it is unclear which type of immune responses enables uncontrolled invasion of opportunistic pathogens. The conditional pathogenicity of Pseudomonas aeruginosa served as an inspiration to begin a study on this bacterium. The aim of this study was to gain insight into selected parameters describing immune responses with regards to the adaptable agents of this pathogen. For the analysis of the specific immune response, the potential of Pseudomonas aeruginosa to stimulate lymphocytes, including Th17 lymphocytes, dendritic cells and other components of the adaptive immune response, was examined. The highest percentage of CD83+CD1a-HLA-DR++ cells was found after stimulation with lysates of strains isolated from the patients with severe systemic infection. We found statistically significant differences in percentages of HLA-DR+ PBMCs and MFI of HLA-DR between groups of Pseudomonas aeruginosa strains isolated from the patients with different clinical courses of infection. Our results suggest that the clinical course and outcomes of Pseudomonas aeruginosa infections are not associated with impairment of the specific immune response.
Highlights
The human immune system is constantly interacting with the external environment, as well as many pathogens
This bacterium is the main epidemiological factor of chronic pneumonia in people with cystic fibrosis (CF), and the long-term immune response of these patients to the presence of Pseudomonas aeruginosa causes the final destruction of the lungs by inflammatory factors, tragically closing the pathogen–host vicious cycle [3]
By use of flow cytometry, we evaluated the influence of individual bacterial lysates on dendritic cell maturation
Summary
The human immune system is constantly interacting with the external environment, as well as many pathogens. Pseudomonas aeruginosa is a very important epidemiological problem of nosocomial infections characterized by a treatment-resistant course, including pneumonia, and including those associated with the use of artificial ventilation, intra-abdominal infections after surgery, burn wounds, meningeal infections and sepsis. This bacterium is the main epidemiological factor of chronic pneumonia in people with cystic fibrosis (CF), and the long-term immune response of these patients to the presence of Pseudomonas aeruginosa causes the final destruction of the lungs by inflammatory factors, tragically closing the pathogen–host vicious cycle [3]. Another important ophthalmological problem is keratitis, which quickly becomes aggressive and erosive [4,5,6,7,8]
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