Abstract
Using immunohistochemical methods, we studied cellular infiltrations of burn wounds in children. The relative number of cells with cluster of differentiation 3 (CD3) CD68 molecules, cells with receptors for interleukin-2 (IL-2) and its receptor (IL-2R), IL-3, IL-3R, IL-6, IL-6R, tumor necrosis factor-alpha (TNF-alpha), TNF-alphaR, and cells with TNF-alpha molecules on their surface was studied. The relationships between these values were determined. The following results were observed: (1) A positive correlation between the relative numbers of CD68 cells and the percentage of cells with receptors for IL-2 (IL-2R) and TNF-alpha (TNF-alphaR); (2) A negative correlation between the relative numbers of CD3 cells and cells with receptors for IL-2 and TNF-alpha; (3) A strong negative correlation between the relative numbers of CD3 and CD68 cells; (4) A positive correlation between the percentage of cells with receptors for TNF-alpha and the size of the burn wound; and (5) A positive correlation between the relative numbers of cells with the TNF-alpha molecule on their surfaces and studied receptors for interleukins, i.e., IL-2R, IL-3R, IL-6R, and TNF-alphaR. These results indicate a key role for TNF-alpha and its receptor within the cytokine system in the course of the inflammatory reaction in burn wounds.
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