Abstract
Cleome rutidosperma DC. (Capparidaceae) traditionally used medicine for insomnia and depression management. The aim of the recent study conducted to investigate the sedative and hypnotic activities of ethanolic extract from the leaves of C. rutidosperma (EECR) in Swiss Albino mice. Neuropharmacological test on mice employed to this study sedative (open field, hole cross, hole- board and rota-rod tests) and hypnotic (thiopental sodium-induce sleeping test) activities of EECR in mice model. The acute toxicity study and phytochemical analysis of EECR also carried out. EECR exhibits significant (p<0.001) sedative effect by decreasing the number of (square and hole) crossed by mice in open field and hole cross tests as a dose-dependent (100-400mg/kg) manner. Hole-board test significantly (p<0.001) decreased the number of head dips and showed the similar effect as diazepam (1mg/kg) in a dose-dependent manner. Rota-rod test also explicit significant (p<0.001) decreased the performance time as well as increased number of falls in a dose-dependent manner. Thiopental sodium-induce sleeping test expressed that EECR significantly (p<0.001) produce shortening latency period and prolonging the sleeping time in a dose-dependent (100- 400mg/kg) manner. The experimental result indicates, C. rutidosperma containing phytochemicals that possess sedative and hypnotic activity which traditionally used as insomnia and depression management.
 
 Keywords: Cleome rutidosperma; Capparidaceae; Sedative; Hypnotic; Phytochemicals
Highlights
Natural products found from plants have been conveying a vital role among human being since ancientJ Pharm Sci Therap, 4(1):215-223 (2018)times
The quantitative phytochemical analysis of extract from the leaves of C.rutidosperma (EECR) expressed the presence of alkaloids, glycosides, flavonoids, tannins, saponins, steroids and reducing sugar (Table 1)
During observation treated mouse with diazepam and EECR positioned at the center of holeboard and recorded the head dips with both eyes for 5 minutes
Summary
Natural products found from plants have been conveying a vital role among human being since ancientJ Pharm Sci Therap, 4(1):215223 (2018)times. C.rutidosperma has found in different parts of tropical America and Southeast Asia as well as the naturalized plant [2]. C.rutidosperma has been well-studied by different researchers. The ancient people used various parts of Cleome genus like roots, leaves, and seeds as antiscorbutic, anthelmintic, rubefacient, vesicant and carminative [3]. C.rutidosperma was traditionally popular among ancient people as the treatment of paralysis, epilepsy, convulsions, spasm, and earache, different kind of pain and skin disease [4]. No scientific literature reported about sedative and hypnotic activity of C.rutidosperma. Due to the lack of knowledge and traditional use, we are convinced to design our recent study explores C.rutidosperma leaves sedative and hypnotic activity in the mice models
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