Abstract
Introduction: One of the reasons for persistent endodontic infection is the retention of microorganism on root canal walls. Studies on endodontic prognosis have demonstrated that the addition of antibiotics to the root canal sealer is proven to be beneficial to prevent re-infection and impart antimicrobial property for a longer time. Aims and Objectives: The primary aim of this study is to determine and the secondary aim is to compare the sealing ability of Kerr Pulp Canal Sealer (extended working time) (PCS [EWT]) when used with or without various antibiotic additives viz.; amoxycillin, doxycycline and metronidazole using apical dye leakage method. Materials and Methods: An in vitro study was performed on extracted human teeth, obturated with sealer-antibiotic combinations and sealers alone. Rhodamine-B dye penetration was done for 10 days and the teeth were sectioned and viewed under light microscope; then linear dye penetration was measured and statistically analyzed. Results: Kerr PCS (EWT) showed mean apical leakage of 3.475 mm (P = 0.655, Z = 0.447), whereas PCS (EWT) combined with amoxycillin showed a mean apical leakage of 0.997 mm (P = 0.084, Z = 1.727) showing its clinical significance. PCS (EWT) + amoxycillin showed the best sealing ability with least apical leakage. Conclusion: Addition of antibiotics such as amoxycillin, doxycycline and metronidazole to Kerr PCS (EWT) sealer is recommended as it helps to improve the antibacterial property and the apical sealing ability.Clinical Relevance to Interdisciplinary DentistryBacteria and by-products in the dentinal tubules can cause reinfection of root canal treated teeth.The continuous release of antibacterial agent is desirable to prevent reinfection in root canal treated teeth.This original research hopes to prevent reinfection under the restorations of endodontically treated teeth by the action of additives in root canal sealers and by controlling the microleakage.
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