Evaluation Of Safety And Efficacy Of Pantoprazole And Domperidone Combination In Patients With Gastroesophageal Reflux Disease

Abstract

Background: Gastro-esophageal reflux disease (GERD) and non ulcer dyspepsia (NUD) are overlapping disorders with common symptomatology. The combination is synergistic by decreasing acid production as well as increasing lower esophageal tone & esophageal clearance thus producing a better therapeutic response. Objective: To evaluate the safety and efficacy of the combination Methods: In patients satisfying the inclusion and exclusion criteria for GERD (Group A, n=105) and Non Erosive GERD (Group B, n=19) baseline symptomatology, endoscopy & laboratory investigations were done followed by test medication once daily for 28 days & monitored for symptom improvement at week 1, 2, & 4 and endoscopy and laboratory investigations at week 4. Results: Of Group A patients having erosive GERD 68/94 (72.34%) were completely cured, 19/94 (20.21%) partially cured, 7/94 (7.44%) not cured. All patients having Non-Erosive GERD had significant improvement in symptoms at 4 week from baseline. Conclusion: Combination of pantoprazole and domperidone is a effective & safe combination with high symptom improvement rates.