Abstract
BackgroundRumex hastatus leaves have been widely used as food additive and for the treatment of various liver ailments. According to our previous studies, ethyle acetate (ERL) and methanolic (MRL) fractions of R. hastatus leaves are an accessible source of natural antioxidants. In the present research work we arranged to investigate the R. hastatus leaves as hepaptoprotective agent verse hepatic damages caused by CCl4.MethodsDuring this project we divided 48 rats into eight groups randomly. CCl4-induced damages were assessed through liver function markers viz.; alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), γ-glutamyltransferase (γ-GT) and lactate dehydrogenase (LDH). Changes in lipid profile were checked by measuring serum total cholesterol (TC), triglycerides (Tg), high density lipoproteins (HDL) and low density lipoproteins (LDL). Antioxidant status was checked by the activities of antioxidant enzymes, DNA damages and cellular abnormalities at histo level.ResultsAdministration of CCl4 in rats caused significant increase in liver function and lipid profile indicating hepatic damages which were restored by co-administration of R. hastatus extracts. Cellular and DNA damages in hepatic tissues were caused by CCl4 which shown clear hepatic fibrosis in addition to disturb antioxidant enzyme level. Co-treatment with various fractions of R. hastatus leaves regulated these markers of oxidative dysfunctions.ConclusionFrom the present report it was inferred that R. hastatus leaves have the ability to reverse CCl4 - induced hepatic damages.
Highlights
Rumex hastatus leaves have been widely used as food additive and for the treatment of various liver ailments
Liver fibrosis is an irreversible alteration in the architecture of standard body cells and tissues caused by prolonged hepatic damages, including drug and chemical toxicity
Our previous studies verified that the R. hastatus leaves are used as a good antioxidant source with sufficient amount of phenolics [7]
Summary
Rumex hastatus leaves have been widely used as food additive and for the treatment of various liver ailments. In the present research work we arranged to investigate the R. hastatus leaves as hepaptoprotective agent verse hepatic damages caused by CCl4. Multiple reports revealed that these free radicles depleted the antioxidant enzymatic and non-enzymatic levels which are linked to hepatic injuries and fibrosis [3]. To control such damages various ways of. Our previous studies verified that the R. hastatus leaves are used as a good antioxidant source with sufficient amount of phenolics [7]. Sahreen et al [9] reported that various fractions of Rumex hastatus roots
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