Abstract
Introduction: Cervical cancer is the second most common malignancy among women all over the world and a leading cause of death in females. There are known risk factors in this regard including immunosuppression condition like SLE. Screening of women could decrease the incidence of cervical cancer dramatically by detection of early premalignant changes in the tissue. There was significant debate as female with SLE did in fact have an increased risk of cancer compared to the general population. Our study was conducted to determine the prevalence of abnormal cervical smear and colposcopy finding in patients with SLE. Patients and methods: Our study was carried out on 128 participants (64 SLE patients and 64 apparently healthy individuals as a control group). Patients were recruited from Rheumatology, Obstetrics and Gynecology Department of Armed Forces Hospitals of South Region. Gazan, KSA. The study was explained to all patients and informed consent was obtained before enrollment in the study. All patients underwent thorough complete history taking, clinical evaluation, local and bimanual examination, speculum examination with pap smear intake, colposcopy examination to whom have abnormal pap smear patients with suspicious area, multiple biopsies where be taken for histopathologic examination. Results: The results of our study demonstrated that, there is a significant association between cervical cancer and SLE patients (p=0.034). There is a significant association between ASCUS (Atypical squamous cells of undetermined significance) with younger age of marriage (p=0.019) and shorter duration of SLE (0.014). There is a significant association between cervical cancer with coital bleeding and history of cervical lesion (p=0.003). There is a high significant association between cervical cancer (especially ASCUS and CIN II) with passive smoking. Other examined parameters did not show any significant association (p>0.05).
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