Abstract
Purpose The aim of this work was to analyze clinical features and laboratory findings of children with adenovirus pneumonia and guide clinical diagnosis, treatment, and assessment of disease severity. Material and Methods. Retrospective analysis of clinical data of 285 children with adenoviral pneumonia who were hospitalized in Wuhan Children's Hospital from December 2018 to October 2019. According to the assessment criteria for severe pneumonia, it was divided into the severe group (92 cases) and the nonsevere group (193 cases). Collected clinical manifestations, complications, and laboratory test indicators in two groups of children and conducted all statistical analyses. Results The risk of fever and wheezing was significantly higher in the severe group than in the nonsevere group. The difference was statistically significant (P < 0.05). The risk of complications in the severe group was significantly higher than that in the nonsevere group. The difference was statistically significant (P < 0.05). The levels of AST, LDH-L, PCT, ferritin, and D-dimer in the severe group were significantly higher than those in the nonsevere group. The difference was statistically significant (P < 0.05). Conclusion Children with severe adenovirus pneumonia have severe clinical manifestations and many complications. AST, LDH-L, PCT, ferritin, and D-dimer levels have important clinical implications for assessing disease severity.
Highlights
Adenoviruses (AdV) are DNA viruses that typically cause infections involving the upper or lower respiratory tract, gastrointestinal (GI) tract, or conjunctiva
It was recommended that all children admitted to the hospital undergo routine testing for respiratory viruses, bacteria, and fungi. 285 cases of adenoviral pneumonia treated in our hospital were selected as the research objects
According to the symptoms and signs presented in the children, 285 children with adenoviral pneumonia were divided into the severe group (92 cases) and the nonsevere group (193 cases)
Summary
Adenoviruses (AdV) are DNA viruses that typically cause infections involving the upper or lower respiratory tract, gastrointestinal (GI) tract, or conjunctiva. Adenovirus infections are more common in young children, which is more common in 6-month to 2-year-old infants owing to lack of humoral immunity [1, 2]. Fatality rates for untreated severe AdV pneumonia or disseminated disease may exceed 50%. Severe adenoviral pneumonia has an acute onset, severe illness, rapid progress, and a poor prognosis [3]. The incidence of severe adenoviral pneumonia in the winter and spring seasons of 2018 in Hubei has increased. This study analyzed clinical data of 285 children with adenoviral pneumonia admitted in our hospital and provided evidence-based medical evidence for the early diagnosis, timely and active treatment of severe cases, and improved prognosis
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