Evaluation of right ventricular systolic function and effects of maintenance hemodialysis on it in uremic patients by 4D RV Volume

Abstract

Objective To evaluate the right ventricular systolic function in uremia patients and the effects of maintenance hemodialysis on right ventricular systolic function by volume and strain parameters obtained by 4D RV Volume. Methods Seventy-six patients with uremia and twenty-two controls were selected. According to left ventricular ejection fraction (LVEF), uremia patients were divided into normal LVEF uremia group and decreased LVEF uremia group. Then normal LVEF uremia group was divided into maintenance hemodialysis group and non-dialysis group. Conventional ultrasound parameters included: LVEF, pulmonary artery systolic pressure (PASP) and tricuspid annular plane systolic excursion (TAPSE-2D). 4D RV Volume parameters included: right ventricular end-diastolic volume (RVEDV), tricuspid annular plane systolic excursion (TAPSE-4D), right ventricular area change rate (FAC), right ventricular ejection fraction (RVEF) and right ventricular free wall longitudinal systolic strain (RV-GLSfree). Results ①Compared with the control group, TAPSE-2D decreased significantly in the decreased LVEF uremia group (P 0.05). Compared with the control group and normal LVEF uremia group, PASP increased significantly in the decreased LVEF uremia group (P 0.05). Compared with the control group, PASP and RVEDV increased and TAPSE-4D, FAC, RVEF and RV-GLSfree decreased significantly in uremia hemodialysis group and non-dialysis group (P 0.05). Conclusions 4D RV Volume could early and accurately evaluate the right ventricular systolic dysfunction in uremia patients. Furthermore, when evaluating right ventricular systolic function in uremia patients treated with maintenance hemodialysis, indices such as right ventricular strain and volume parameters should be comprehensively considered. Key words: Ultrasonography; Uremia; Ventricular function, right; Dialysis; 4D RV Volume; Three-dimensional strain