Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with Optic Neuritis or Neuromyelitis Optica Spectrum Disorders Using Optical Coherence Tomography in a Chinese Cohort.

Guohong Tian,Yongheng Huang,Zhenxin Li,Xinghuai Sun,Mengwei Li,Guixian Zhao,Chaoyi Feng

doi:10.1155/2015/832784

Guohong Tian, Yongheng Huang + Show 5 more

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https://doi.org/10.1155/2015/832784

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Journal: Journal of ophthalmology	Publication Date: Jan 1, 2015
Citations: 19	License type: CC BY 3.0

Affiliation: Huashan Hospital, Fudan University

Abstract

We evaluate a cohort of optic neuritis and neuromyelitis optica (NMO) spectrum disorders patients in a territory hospital in China. The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were measured using spectral-domain OCT after 6 months of acute onset. The results showed that both the peripapillary RNFL and macular GCC were significantly thinner in all optic neuritis subtypes compared to controls. In addition, the recurrent optic neuritis and NMO groups showed more severe damage on the RNFL and GCC pattern.

Highlights

Acute optic neuritis may be the first manifestation of both multiple sclerosis (MS) and neuromyelitis optica (NMO), or some unknown etiology of disorders [1, 2]
Among the MSON group, 6 patients were diagnosed with clinical definite MS with optic neuritis; 4 patients had presented with clinical isolate syndrome (CIS) with brain or brainstem demyelinated lesion and subsequently got optic neuritis; the other 52 patients presented with isolated acute optic neuritis fulfilling the idiopathic demyelinating etiology after thorough ancillary work-up
Optic neuritis is one of the common optic neuropathies, which lead to visual loss in young Chinese and the underline etiologies have not been full clarified [1]

Summary

Introduction

Acute optic neuritis may be the first manifestation of both multiple sclerosis (MS) and neuromyelitis optica (NMO), or some unknown etiology of disorders [1, 2]. In Chinese, the demographic and clinical features of optic neuritis spectrum disorder are less well-defined than that in Caucasus [3,4,5]. During the past few years, numerous studies showed that peripapillary RNFL and macular thickness analysis may be used to detect axonal loss in optic neuritis, neuromyelitis optica, and other forms of chronic relapsing optic neuritis [6,7,8,9]. The propose of this study was to evaluate the thickness of the RNFL and macular GCC using SD-OCT in different forms of optic neuritis in a cohort of Chinese patients and compare the pattern of damage in MS-ON, NMO-ON, and R-ON group

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Results

Conclusion